منابع مشابه
Roles of FAK family kinases in nervous system.
Focal adhesion kinase (FAK) and its related kinase, proline rich tyrosine kinase 2 (PYK2), are major kinases activated by cell-extracellular matrix adhesion. Although they are highly expressed in the nervous system, the functions of these two kinases in the nervous system remained unclear until recently. FAK and PYK2 appear to play an important role in developing nervous system as well as adult...
متن کاملDifferential expression of the FAK family kinases in rheumatoid arthritis and osteoarthritis synovial tissues
The focal adhesion kinase (FAK) family kinases, including FAK and proline-rich kinase 2 (Pyk)2, are the predominant mediators of integrin alphavbeta3 signaling events that play an important role in cell adhesion, osteoclast pathology, and angiogenesis, all processes important in rheumatoid arthritis (RA). Using immunohistochemical and western blot analysis, we studied the distribution of phosph...
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Coronary heart diseases are the most preventable non-contagious diseases, but unfortunately, ‎it is one of the major causes of mortality among humans in the industrialized and semi-‎industrialized countries. It is predicted that if this trend continues, it will lead to the death of ‎approximately over ‎‏25‏‎ million people in the world by ‎‏2020‏‎. On...
متن کاملPAK family kinases
The p21-activated kinases (PAKs) are a family of Ser/Thr protein kinases that are represented by six genes in humans (PAK 1-6), and are found in all eukaryotes sequenced to date. Genetic and knockdown experiments in frogs, fish and mice indicate group I PAKs are widely expressed, required for multiple tissue development, and particularly important for immune and nervous system function in the a...
متن کاملKey roles of Src family tyrosine kinases in the integrity of the pulmonary vascular bed.
T he pulmonary blood vessels have unique structural and functional properties. The pulmonary circulation is a high-flow, low-resistance, low-pressure system, which is mainly explained by two important characteristics of the pulmonary vascular bed: a high compliance of the pulmonary pre-capillary arterioles characterised by thin media and a high capacity to recruit vessels available to cope with...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2020
ISSN: 1422-0067
DOI: 10.3390/ijms21103630